Thomas County was created in 1825 from portions of Decatur and Irwin counties. Georgia’s 63rd county, and its county seat, Thomasville, were named for a hero of the War of 1812, General Jett Thomas. In addition to his military career, General Thomas built the first university building in Athens.

Ochlocknee is named for the river flowing through Thomas County. Pavo, Latin for Peacock, was named after the first postmaster in the area.